Sirtuin1 Regulates the Stem Cell Therapeutic Effects on Regenerative Capability for Treating Severe Heart Failure in a Juvenile Animal Model.

@article{Ozawa2016Sirtuin1RT,
  title={Sirtuin1 Regulates the Stem Cell Therapeutic Effects on Regenerative Capability for Treating Severe Heart Failure in a Juvenile Animal Model.},
  author={Hideto Ozawa and Shigeru Miyagawa and Satsuki Fukushima and Emiko Itoh and Akima Harada and Atsuhiro Saito and Takayoshi Ueno and Koichi Toda and Toru Kuratani and Yoshiki Sawa},
  journal={The Annals of thoracic surgery},
  year={2016},
  volume={102 3},
  pages={803-812}
}
BACKGROUND This study hypothesized that autologous cell transplantation therapy could have greater therapeutic efficacy in juvenile patients than in adult patients, related to differences in sirtuin1 (SIRT1) expression in transplanted cells. METHODS A model of heart failure was established in mini-pigs by using coronary artery occlusion. Stem cell… CONTINUE READING