Sirtuin modulators.

  title={Sirtuin modulators.},
  author={Sumit S. Mahajan and Vid Leko and Julian A Simon and Antonio Bedalov},
  journal={Handbook of experimental pharmacology},
Members of the sirtuin family including the founding protein Sir2 in Saccharomyces cerevisiae have been linked to lifespan extension in simple organisms. This finding prompted evaluation of the role of Sir2 orthologues in many aging-associated conditions including neurodegeneration, type II diabetes and cancer. These studies have demonstrated that genetic and pharmacologic manipulation of sirtuin activity have beneficial effects in a surprisingly broad spectrum of aging-associated conditions… CONTINUE READING