Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer’s disease

  title={Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer’s disease},
  author={Caterina Scuderi and Claudia Stecca and Maria Rosanna Bronzuoli and Dante Rotili and Sergio Valente and Antonello Mai and Luca Steardo},
  booktitle={Front. Pharmacol.},
Among neurodegenerative disorders, Alzheimer's disease (AD) represents the most common cause of dementia in the elderly. Several genetic and environmental factors have been identified; however, aging represents the most important risk factor in the development of AD. To date, no effective treatments to prevent or slow this dementia are available. Sirtuins (SIRTs) are a family of NAD(+)-dependent enzymes, implicated in the control of a variety of biological processes that have the potential to… CONTINUE READING
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