Sirtuin modulators: mechanisms and potential clinical implications.

  title={Sirtuin modulators: mechanisms and potential clinical implications.},
  author={Susana S{\'a}nchez-Fidalgo and Isabel Villegas and Marina S{\'a}nchez-Hidalgo and Catalina Alarc{\'o}n de la Lastra},
  journal={Current medicinal chemistry},
  volume={19 15},
In the last years, studies about longevity have highlighted that caloric restriction can be linked with a less normal agingassociated damage, and in the same way, with the activity of the Silent Information Regulator 2 (SIR2) gene. Sir2-like genes, known as sirtuins (SIRTs), have been found in organisms ranging from bacteria to mammals promoting health and survival. At the moment, it has been identified seven classes of SIRTs in mammalian and the understanding of many of them remains still… CONTINUE READING


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