Sirtuin inhibitors.

  title={Sirtuin inhibitors.},
  author={Francisco Javier Alca{\'i}n and J. M. Villalba},
  journal={Expert opinion on therapeutic patents},
  volume={19 3},
BACKGROUND The sirtuin family of deacetylase enzymes comprises seven proteins (SIRT1-7) that are dependent on NAD(+) for their activity. Three proteins are located in the nucleus, three in the mitochondria and only one is predominantly cytoplasmic. Caloric restriction and oxidative stress generally up-regulate their expression. SIRT1, the orthologue of yeast Sir2, is the mammalian sirtuin that has been most extensively studied to date. Among other targets, SIRT1 down-regulates the activity of… CONTINUE READING