Sirtuin activators mimic caloric restriction and delay ageing in metazoans

  title={Sirtuin activators mimic caloric restriction and delay ageing in metazoans},
  author={J. G. Wood and B. Rogina and Siva Lavu and K. Howitz and S. Helfand and M. Tatar and D. Sinclair},
  • J. G. Wood, B. Rogina, +4 authors D. Sinclair
  • Published 2004
  • Biology, Medicine
  • Nature
  • Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast. Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without… CONTINUE READING
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