Sirtuin activators mimic caloric restriction and delay ageing in metazoans

@article{Wood2004SirtuinAM,
  title={Sirtuin activators mimic caloric restriction and delay ageing in metazoans},
  author={Jason G. Wood and Blanka Rogina and Siva Lavu and Konrad T. Howitz and Stephen L. Helfand and Marc Tatar and David Sinclair},
  journal={Nature},
  year={2004},
  volume={430},
  pages={686-689}
}
Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast. Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without… 
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Calorie Restriction— the SIR2 Connection
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The findings indicate that SIRT1 can influence many of the major diseases of aging, including metabolic diseases like diabetes, neurodegenerative diseases (Alzheimer's and Huntington's), cancer and osteoporosis, and small molecules that alter the activity of Sirt1 (i.e. CR mimetic drugs) offer a new approach to prevent and possibly treat the major Diseases of aging.
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