Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.

@article{Mao2012Sirtuin6,
  title={Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.},
  author={Zhiyong Mao and Xiao Tian and Michael Van Meter and Zhonghe Ke and Vera Gorbunova and Andrei Seluanov},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 29},
  pages={
          11800-5
        }
}
Genomic instability is a hallmark of aging tissues. Genomic instability may arise from the inefficient or aberrant function of DNA double-stranded break (DSB) repair. DSBs are repaired by homologous recombination (HR) and nonhomologous DNA end joining (NHEJ). HR is a precise pathway, whereas NHEJ frequently leads to deletions or insertions at the repair site. Here, we used normal human fibroblasts with a chromosomally integrated HR reporter cassette to examine the changes in HR efficiency as… CONTINUE READING
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