Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.

@article{Paulin2014Sirtuin3D,
  title={Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.},
  author={Roxane Paulin and Peter Dromparis and Gopinath Sutendra and Vikram Gurtu and Sotirios Zervopoulos and Lyndsay Bowers and Alois Haromy and Linda Webster and Steeve Provencher and S{\'e}bastien Bonnet and Evangelos D. Michelakis},
  journal={Cell metabolism},
  year={2014},
  volume={20 5},
  pages={
          827-839
        }
}
Suppression of mitochondrial function promoting proliferation and apoptosis suppression has been described in the pulmonary arteries and extrapulmonary tissues in pulmonary arterial hypertension (PAH), but the cause of this metabolic remodeling is unknown. Mice lacking sirtuin 3 (SIRT3), a mitochondrial deacetylase, have increased acetylation and inhibition of many mitochondrial enzymes and complexes, suppressing mitochondrial function. Sirt3KO mice develop spontaneous PAH, exhibiting… CONTINUE READING

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