Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival.

Abstract

Sirtuin 1 (Sirt1), a class III histone/protein deacetylase, is central to cellular metabolism, stress responses, and aging, but its contributions to various host immune functions have been little investigated. To study the role of Sirt1 in T cell functions, we undertook targeted deletions by mating mice with a floxed Sirt1 gene to mice expressing CD4-cre or… (More)
DOI: 10.1128/MCB.01206-10

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Cite this paper

@article{Beier2011Sirtuin1TP, title={Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival.}, author={Ulf Henning Beier and Liqing Wang and Tricia R. Bhatti and Yujie Liu and Rongxiang Han and Guanghui Ge and Wayne W. Hancock}, journal={Molecular and cellular biology}, year={2011}, volume={31 5}, pages={1022-9} }