Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise.

Abstract

The protein deacetylase, sirtuin 1 (SIRT1), is a proposed master regulator of exercise-induced mitochondrial biogenesis in skeletal muscle, primarily via its ability to deacetylate and activate peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). To investigate regulation of mitochondrial biogenesis by SIRT1 in vivo, we generated mice… (More)
DOI: 10.1074/jbc.M111.261685

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@article{Philp2011Sirtuin1, title={Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise.}, author={Andrew Philp and Ai Chen and Debin Lan and Gretchen A. Meyer and Anne N Murphy and Amy E Knapp and I. Mark Olfert and Carrie E. McCurdy and George R. Marcotte and Michael C Hogan and Keith R Baar and Simon Schenk}, journal={The Journal of biological chemistry}, year={2011}, volume={286 35}, pages={30561-70} }