Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

@inproceedings{Jing2013Sirt3RM,
  title={Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation},
  author={Enxuan Jing and Brian T O'Neill and Matthew J Rardin and Andr{\'e} Kleinridders and Olga R. Ilkeyeva and Siegfried Ussar and James R. Bain and Kevin Y Lee and Eric Verdin and Christopher B Newgard and Bradford W. Gibson and C Ronald Kahn},
  booktitle={Diabetes},
  year={2013}
}
Sirt3 is an NAD(+)-dependent deacetylase that regulates mitochondrial function by targeting metabolic enzymes and proteins. In fasting mice, Sirt3 expression is decreased in skeletal muscle resulting in increased mitochondrial protein acetylation. Deletion of Sirt3 led to impaired glucose oxidation in muscle, which was associated with decreased pyruvate dehydrogenase (PDH) activity, accumulation of pyruvate and lactate metabolites, and an inability of insulin to suppress fatty acid oxidation… CONTINUE READING

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