Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

  title={Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ},
  author={Fr{\'e}d{\'e}ric Picard and Martin V. Kurtev and Namjin Chung and Acharawan Topark-Ngarm and Thanaset Senawong and Rita Machado de Oliveira and Mark E Leid and Michael W McBurney and Leonard P. Guarente},
Calorie restriction extends lifespan in organisms ranging from yeast to mammals. In yeast, the SIR2 gene mediates the life-extending effects of calorie restriction. Here we show that the mammalian SIR2 orthologue, Sirt1 (sirtuin 1), activates a critical component of calorie restriction in mammals; that is, fat mobilization in white adipocytes. Upon food withdrawal Sirt1 protein binds to and represses genes controlled by the fat regulator PPAR-γ (peroxisome proliferator-activated receptor… CONTINUE READING
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