Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells.

@article{Breitenstein2011Sirt1IP,
  title={Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells.},
  author={Alexander Breitenstein and Sokrates M. A. Stein and Erik Walter Holy and Giovanni G Camici and Christine Lohmann and Alexander Akhmedov and Remo D. Spescha and Peter J. Elliott and Christoph Westphal and Christian M Matter and Thomas Felix L{\"u}scher and Felix C. Tanner},
  journal={Cardiovascular research},
  year={2011},
  volume={89 2},
  pages={464-72}
}
AIMS The mammalian silent information regulator-two 1 (Sirt1) blunts the noxious effects of cardiovascular risk factors such as type 2 diabetes mellitus and obesity. Nevertheless, the role of Sirt1 in regulating the expression of tissue factor (TF), the key trigger of coagulation, and arterial thrombus formation remains unknown. METHODS AND RESULTS Human as well as mouse cell lines were used for in vitro experiments, and C57Bl/6 mice for in vivo procedures. Sirt1 inhibition by splitomicin or… CONTINUE READING