Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

@article{Herranz2010Sirt1IH,
  title={Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.},
  author={Daniel Herranz and M. {\'A}ngeles Mu{\~n}oz-Mart{\'i}n and M. Ά. Bl{\'a}zquez Ca{\~n}amero and Francisca Mulero and B{\'a}rbara Mart{\'i}nez-Pastor and Oscar Fern{\'a}ndez-Capetillo and Manuel Serrano},
  journal={Nature communications},
  year={2010},
  volume={1},
  pages={
          3
        }
}
Genetic overexpression of protein deacetylase Sir2 increases longevity in a variety of lower organisms, and this has prompted interest in the effects of its closest mammalian homologue, Sirt1, on ageing and cancer. We have generated transgenic mice moderately overexpressing Sirt1 under its own regulatory elements (Sirt1-tg). Old Sirt1-tg mice present lower levels of DNA damage, decreased expression of the ageing-associated gene p16(Ink4a), a better general health and fewer spontaneous… CONTINUE READING
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