Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy.


Sirt1 is a human homologue of the silent information regulator factor 2 (Sir2) and has an NAD+-dependent histone deacetylase activity. This protein is reported to have a pathogenetic role in muscle differentiation, diabetic nephropathy, and heart failure. In this study, we investigated the expression of sirt1 in spontaneously hypertensive rat (SHR) to… (More)
DOI: 10.1139/Y08-099


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