Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.

@article{Satoh2013Sirt1EL,
  title={Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.},
  author={Akiko Satoh and Cynthia S. Brace and Nick Rensing and Paul F. Cliften and David F. Wozniak and Erik D. Herzog and Kelvin A. Yamada and Shin-ichiro Imai},
  journal={Cell metabolism},
  year={2013},
  volume={18 3},
  pages={416-30}
}
The mammalian Sir2 ortholog Sirt1 plays an important role in metabolic regulation. However, the role of Sirt1 in the regulation of aging and longevity is still controversial. Here we demonstrate that brain-specific Sirt1-overexpressing (BRASTO) transgenic mice show significant life span extension in both males and females, and aged BRASTO mice exhibit phenotypes consistent with a delay in aging. These phenotypes are mediated by enhanced neural activity specifically in the dorsomedial and… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 20 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 139 extracted citations

A brief history of modern aging research

Experimental Gerontology • 2018
View 2 Excerpts

Antioxidant and Antisenescence Effects of Bergamot Juice

Oxidative medicine and cellular longevity • 2018
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Sleep as a fundamental property of neuronal assemblies

Nature Reviews Neuroscience • 2008
View 4 Excerpts
Highly Influenced

Sirtuin catalysis and regulation.

The Journal of biological chemistry • 2012
View 1 Excerpt

Absence of Cell Me effects of Sir 2 overexpression on lifespan in C . elegans and Drosophila

C. Burnett, S. Valentini, +7 authors J. J. McElwee
Nature • 2011
View 2 Excerpts

Similar Papers

Loading similar papers…