Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction.

@article{Schenk2011Sirt1ES,
  title={Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction.},
  author={Simon Schenk and Carrie E McCurdy and Andrew Philp and Mark Z. Chen and Michael J Holliday and Gautum K Bandyopadhyay and Olivia Osborn and K Baar and Jerrold M. Olefsky},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 11},
  pages={4281-8}
}
Skeletal muscle insulin resistance is a key component of the etiology of type 2 diabetes. Caloric restriction (CR) enhances the sensitivity of skeletal muscle to insulin. However, the molecular signals within skeletal muscle linking CR to improved insulin action remain largely unknown. Recently, the mammalian ortholog of Sir2, sirtuin 1 (Sirt1), has been identified as a potential transducer of perturbations in cellular energy flux into subsequent metabolic adaptations, including modulation of… CONTINUE READING

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