Sirolimus solid self-microemulsifying pellets: formulation development, characterization and bioavailability evaluation.

@article{Hu2012SirolimusSS,
  title={Sirolimus solid self-microemulsifying pellets: formulation development, characterization and bioavailability evaluation.},
  author={Xiongwei Hu and Chen Lin and Dingxiong Chen and Jiawei Zhang and Zhihong Liu and Wei Chen Wu and Hongtao Song},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={438 1-2},
  pages={123-33}
}
To enhance the dissolution and oral absorption of water insoluble drug sirolimus (SRL), self-microemulsifying pellets of SRL were developed and evaluated. Solubility test, self-emulsifying grading test, ternary phase diagrams and central composite design were adopted to screen and optimize the composition of liquid SRL-SMEDDS. The selected liquid SRL-SMEDDS formulations were prepared into pellets by extrusion-spheronization method and the optimal formulation of 1mg SRL-SMEDDS pellets capsule (1… CONTINUE READING