Sirolimus (rapamycin) potentiates cyclosporine in prevention of acute lung rejection.

Abstract

BACKGROUND Cyclosporine-based immunosuppressive regimens (INN: ciclosporin) in human lung transplantation continue to result in a high incidence of acute cellular rejection. We investigated the use of sirolimus, a macrolide with structural similarity to tacrolimus, as monotherapy and in combination with cyclosporine in a rodent lung transplant model… (More)

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@article{Longoria1999SirolimusP, title={Sirolimus (rapamycin) potentiates cyclosporine in prevention of acute lung rejection.}, author={Jason A. Longoria and Rachel Roberts and Charles C. Marboe and Bruce C. Stouch and Vaughn A. Starnes and Mark L. Barr}, journal={The Journal of thoracic and cardiovascular surgery}, year={1999}, volume={117 4}, pages={714-8} }