Sirolimus pharmacokinetics in pediatric renal transplant recipients receiving calcineurin inhibitor co-therapy.

@article{Schachter2006SirolimusPI,
  title={Sirolimus pharmacokinetics in pediatric renal transplant recipients receiving calcineurin inhibitor co-therapy.},
  author={Asher D. Schachter and Mark R. Benfield and Robert J Wyatt and Paul C. Grimm and Robert S. Fennell and John T. Herrin and David S. Lirenman and Ruth A. McDonald and Ricardo Mu{\~n}oz-Arizpe and William E. Harmon},
  journal={Pediatric transplantation},
  year={2006},
  volume={10 8},
  pages={914-9}
}
We have previously reported sirolimus (SRL) pharmacokinetics (PK) in pediatric renal transplant recipients on a calcineurin inhibitor (CNI)-free protocol. We now report pediatric SRL PK in pediatric renal transplant patients receiving SRL + CNI. SRL was dosed to achieve target trough levels between 10 and 20 ng/mL. We performed 49 SRL PK profiles in pediatric renal transplant recipients receiving SRL in combination with either cyclosporine (CsA; 25 profiles), or tacrolimus (TCL; 24 profiles… CONTINUE READING
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