Sirolimus-mediated prolongation of rat cardiac allograft survival is enhanced by beta1 integrin very late antigen-4 blockade.

Abstract

The beta1 integrin very late antigen-4 (VLA-4) plays a key role in lymphocyte rolling and adhesion to endothelium, and in lymphocyte migration through fibronectin. Thus, VLA-4 blockade may modulate allograft rejection. Here, we examined the effect of WAY-279, a small molecule VLA-4 antagonist, combined with sirolimus in a model of vascularized heart… (More)

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@article{Vu2005SirolimusmediatedPO, title={Sirolimus-mediated prolongation of rat cardiac allograft survival is enhanced by beta1 integrin very late antigen-4 blockade.}, author={M D Vu and Shuang Qi and Suren N Sehgal and Howard Chen and Jeffrey D. Kennedy}, journal={Transplantation proceedings}, year={2005}, volume={37 1}, pages={162-3} }