Sirolimus may reduce fertility in male renal transplant recipients.

@article{Zuber2008SirolimusMR,
  title={Sirolimus may reduce fertility in male renal transplant recipients.},
  author={Julien Zuber and Dany Anglicheau and Caroline Elie and Lynda Bererhi and M O Timsit and M-F Mamzer-Bruneel and Magali Ciroldi and Frank Martinez and Renaud Snanoudj and Christian Hiesse and Henri A Kreis and Francis Eustache and Kathleen Laborde and Eric Thervet and C H Legendre},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2008},
  volume={8 7},
  pages={1471-9}
}
Assessment of sex hormones in organ transplant recipients suggests that sirolimus may impair testicular function. The aim of this study was to evaluate the frequency and severity of sirolimus-associated alterations in sperm parameters and their impact on fathered pregnancy rate. An observational study was carried out in male patients aged 20-40 years who received a kidney transplant during 1995-2005. Patients were sent a questionnaire by post, and sperm analysis was proposed. The fathered… CONTINUE READING

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High incidence of infertility in men and women kidney transplant patients receiving sirolimus

  • Y Boobes, B Bernieh, R Al Hakim, S. Abouchacra
  • J Am Soc Nephrol
  • 2007
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