Sirolimus interacts with pathways essential for podocyte integrity.

  title={Sirolimus interacts with pathways essential for podocyte integrity.},
  author={Emmanuel Letavernier and Patrick Bruneval and Sophie Vandermeersch and Joelle Perez and Chantal Mandet and M A Belair and Jean-philippe Haymann and C. Legendre and Laurent Baud},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={24 2},
BACKGROUND The specific mTor inhibitor sirolimus has been implicated in the pathogenesis of renal glomerular lesions and nephrotic syndrome appearance after transplantation. Podocyte injury and focal segmental glomerulosclerosis have been related to sirolimus therapy in some patients but the pathways underlying these lesions remain hypothetical. METHODS To go further in the comprehension of these mechanisms, primary cultures of human podocytes were exposed to therapeutic-range concentrations… CONTINUE READING
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