Sirolimus in chronic allograft nephropathy in pediatric recipients.

  title={Sirolimus in chronic allograft nephropathy in pediatric recipients.},
  author={Juan Ib{\'a}{\~n}ez and Marta Lidia Monteverde and Miguel Angel D{\'i}az and Julio Goldberg and Amalia Turconi},
  journal={Pediatric transplantation},
  volume={11 7},
CAN is a common cause of late graft loss. Nephrotoxicity due to CNIs is known to contribute to CAN. We retrospectively evaluated the efficacy and safety of SRL in pediatric renal Tx recipients showing CAN in their allograft biopsy. Twenty-one patients aged 10.4 +/- 4.6 yr at Tx time receiving CNIs as primary immunosuppression were converted to SRL at 58.9 +/- 49.1 months after Tx, due to progressive decline of renal function and biopsy proven CAN. Mean follow-up after switch was 19.7 +/- 9.5… CONTINUE READING