Sirolimus for Retinal Astrocytic Hamartoma Associated with Tuberous Sclerosis Complex.

  title={Sirolimus for Retinal Astrocytic Hamartoma Associated with Tuberous Sclerosis Complex.},
  author={Zhi-qiao Zhang and Cheng Shen and Qin Long and Zhi-kun Yang and Rong-ping Dai and Jun Wang and Weihong Zhang and Qingqing Pan and Zhaohui Zhu and Kaifeng Xu},
  volume={122 9},
Mammalian target of rapamycin inhibitors for the treatment of astrocytic hamartoma in tuberous sclerosis complex (TSC)
The findings of this study suggest that mTOR inhibitors can reduce tumor size and that they can be considered as an optional treatment in certain conditions.
  • Clinical Ophthalmic Genetics and Genomics
  • 2022
Regressed Retinal Astrocytic Hamartomas in Tuberous Sclerosis by Mammalian Target of Rapamycin Inhibitor (Everolimus) Treatment
Purpose: We report a case of regressed retinal astrocytic hamartomas (RAHs) in tuberous sclerosis complex (TSC) patients by mammalian target of rapamycin inhibitor (everolimus) treatment. Case
Retinale Tumoren im Erwachsenenalter – Teil 2: Nichtvaskuläre Tumoren der Retina und des retinalen Pigmentepithels
Retinale Tumoren bilden eine heterogene Gruppe angeborener und erworbener Läsionen. Im zweiten Teil des Beitrags werden die retinozytären und Gliazelltumoren der Retina, Tumoren des retinalen
Clinical features and optical coherence tomography findings of retinal astrocytic hamartomas in Chinese patients with tuberous sclerosis complex
A higher prevalence of TSC-associated RAH but an unexpected lower prevalence of calcified RAHs was shown in Chinese compared with that of Caucasians, suggesting SD-OCT can be used to facilitate the detection and follow-up of RAH's.
Congenital focal abnormalities of the retina and retinal pigment epithelium
A review of the published literature on a group of developmental disorders of the retina and retinal pigment epithelium which result in focal abnormalities in one or both eyes and some are associated with other systemic abnormalities.
Glaucoma secondary to intraocular tumors: mechanisms and management
Intraocular tumors can produce secondary glaucoma, which may involve medical therapy, transscleral cyclophotocoagulation, laser trabeculoplasty, and potentially antivascular endothelial growth factor therapy.
Retinal Astrocytic Tumors


Ophthalmic manifestations of tuberous sclerosis: a population based study
This is the first series to document the statistically significant association of punched out chorioretinal depigmentation with TSC and the authors believe that it should be looked for as an aid to diagnosis.
Ophthalmic Manifestations of Tuberous Sclerosis
  • D. Robertson
  • Medicine
    Annals of the New York Academy of Sciences
  • 1991
Retinoblastoma of the optic nerve and retina is the most important lesion that must be differentiated from the hamartomas seen with tuberous sclerosis.