Sirolimus and paclitaxel provoke different vascular pathological responses after local delivery in a murine model for restenosis on underlying atherosclerotic arteries.

@article{Pires2007SirolimusAP,
  title={Sirolimus and paclitaxel provoke different vascular pathological responses after local delivery in a murine model for restenosis on underlying atherosclerotic arteries.},
  author={Nuno M. M. Pires and Daniel Eefting and Amanda Pronk and Paul H. A. Quax and J Wouter Jukema},
  journal={Heart},
  year={2007},
  volume={93 8},
  pages={922-7}
}
BACKGROUND Drug-eluting stents (DES) have been introduced successfully in clinical practice to prevent post-angioplasty restenosis. Nevertheless, concerns about the safety of DES still exist. OBJECTIVE To investigate the vascular pathology and transcriptional responses to sirolimus and paclitaxel in a murine model for restenosis on underlying diseased atherosclerotic arteries. METHODS Atherosclerotic lesions were induced by placement of a perivascular cuff around the femoral artery of… CONTINUE READING

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