Sirolimus affects cardiomyocytes to reduce left ventricular mass in heart transplant recipients.

@article{Kushwaha2008SirolimusAC,
  title={Sirolimus affects cardiomyocytes to reduce left ventricular mass in heart transplant recipients.},
  author={Sudhir Shyam Kushwaha and Eugenia Raichlin and Yuri Sheinin and Walter K. Kremers and Krishnaswamy Chandrasekaran and Gregory J. Brunn and Jeffrey L Platt},
  journal={European heart journal},
  year={2008},
  volume={29 22},
  pages={
          2742-50
        }
}
AIMS The cellular mechanisms underlying cardiac hypertrophy may result from changes in cardiac myocyte growth and differentiation. We tested whether sirolimus, an immunosuppressive agent that inhibits mTOR, a protein that regulates cell division and differentiation, might modify cardiac hypertrophy after cardiac transplantation. METHODS AND RESULTS Fifty-eight cardiac transplant recipients were withdrawn from treatment with calcineurin inhibitors (CNIs) and treated with sirolimus. Eighty… CONTINUE READING

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  • 2017

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