Sirolimus Immunoprophylaxis and Renal Histological Changes in Long-Term Cardiac Transplant Recipients: A Pilot Study.

@article{White2014SirolimusIA,
  title={Sirolimus Immunoprophylaxis and Renal Histological Changes in Long-Term Cardiac Transplant Recipients: A Pilot Study.},
  author={Michel White and Anne Boucher and Raymond Dandavino and Annik Fortier and Guy B Pelletier and Normand Racine and Anique Ducharme and Simon De Denus and Michel Carrier and Suzon Collette},
  journal={The Annals of pharmacotherapy},
  year={2014},
  volume={48 7},
  pages={837-846}
}
BACKGROUND The effects of sirolimus (SIR), as a substitution for calcineurin inhibitor (CNI) immunoprophylaxis, on renal function in very-long-term cardiac transplant recipients have been a matter of controversy. OBJECTIVE To assess the impacts of SIR as a substitution for CNI on renal function up to 24 months in long-term cardiac recipients as well as the renal histological changes in patients with suspected CNI-induced nephrotoxicity. METHODS A total of 23 cardiac transplant recipients… CONTINUE READING
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