Sirolimus: its discovery, biological properties, and mechanism of action.

  title={Sirolimus: its discovery, biological properties, and mechanism of action.},
  author={Suren N Sehgal},
  journal={Transplantation proceedings},
  volume={35 3 Suppl},
Sirolimus is the USAN-assigned generic name for the natural product rapamycin. Sirolimus is produced by a strain of Streptomyces hygroscopicus, isolated from a soil sample collected from Rapa Nui commonly known as Easter Island. Although sirolimus was isolated as an antifungal agent with potent anticandida activity, subsequent studies revealed impressive antitumor and immunosuppressive activities. Sirolimus demonstrates activity against several murine tumors, such as B16 43 melanocarcinoma… CONTINUE READING
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