SirT 1 represses MMP 13 expression in human articular chondrocytes

  • Dvir-Ginzburg
  • Published 2009
Introduction Osteoarthritis (OA) is a degenerative joint disease of the articular cartilage resulting in the depletion of collagens and proteoglycans due in part to accelerated turnover and inadequate repair. Maintenance of healthy articular cartilage in human adults relies on the optimal expression of a number of unique extracellular matrix genes, such as… CONTINUE READING