SirR, a novel iron-dependent repressor in Staphylococcus epidermidis.

  title={SirR, a novel iron-dependent repressor in Staphylococcus epidermidis.},
  author={Philip J. Hill and Alan Cockayne and Peter Landers and Julie A Morrissey and Calvin M Sims and Paul D. Williams},
  journal={Infection and immunity},
  volume={66 9},
In Staphylococcus epidermidis and Staphylococcus aureus, a number of cell wall- and cytoplasmic membrane-associated lipoproteins are induced in response to iron starvation. To gain insights into the molecular basis of iron-dependent gene regulation in the staphylococci, we sequenced the DNA upstream of the 3-kb S. epidermidis sitABC operon, which Northern blot analysis indicates is transcriptionally regulated by the growth medium iron content. We identified two DNA sequences which are… CONTINUE READING