Sir2 links the unfolded protein response and the heat shock response in a stress response network.

@article{Weindling2015Sir2LT,
  title={Sir2 links the unfolded protein response and the heat shock response in a stress response network.},
  author={Esther Weindling and Shoshana Bar-Nun},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={457 3},
  pages={473-8}
}
The Heat Shock Response (HSR) in the cytosol and the Unfolded Protein Response (UPR) in the endoplasmic reticulum are major pathways of the cellular proteostasis network. In Saccharomyces cerevisiae, HSR is regulated by transcription factor Hsf1, and UPR Ire1 branch activates transcription factor Hac1. Here we demonstrate systemic regulation of proteostasis through a direct link between UPR and HSR. Hsf1 is activated by UPR and its HSR depends on intact UPR. This link is mediated by Sir2, which… CONTINUE READING
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