Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine.

Abstract

Acetyl-coenzyme A (CoA) synthetase (Acs) is an enzyme central to metabolism in prokaryotes and eukaryotes. Acs synthesizes acetyl CoA from acetate, adenosine triphosphate, and CoA through an acetyl-adenosine monophosphate (AMP) intermediate. Immunoblotting and mass spectrometry analysis showed that Salmonella enterica Acs enzyme activity is… (More)

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Cite this paper

@article{Starai2002Sir2dependentAO, title={Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine.}, author={Vincent J Starai and Ivan {\'C}eli{\'c} and Richard Cole and Joern Boeke and Jorge C Escalante-Semerena}, journal={Science}, year={2002}, volume={298 5602}, pages={2390-2} }