Sir John Edward Sulston CH. 27 March 1942—6 March 2018

  title={Sir John Edward Sulston CH. 27 March 1942—6 March 2018},
  author={Robert H. Waterston and Georgina Ferry},
In 2002 Sir John Sulston shared the Nobel Prize for Physiology or Medicine for his contribution to understanding the genetic control of cell fate during the development of the roundworm Caenorhabditis elegans. However, it was his position as one of the leaders of the international and publicly funded Human Genome Project that brought him to public prominence. Both his work on the worm cell lineage and his later commitment to genome sequencing as founding director of the Wellcome Trust Sanger… Expand
1 Citations


Genomics in C. elegans: so many genes, such a little worm.
The Caenorhabditis elegans genome sequence is now complete, fully contiguous telomere toTelomere and totaling 100,291,840 bp, providing a solid platform on which to build toward a true molecular understanding of worm biology with all its implications including those for human health. Expand
YACs and the C. elegans genome.
The application of YACs to the physical map of the Caenorhabditis elegans genome has enabled cosmid clone 'islands' to be linked together in an efficient manner and the long-range continuity has improved the linkage between the genetic and physical maps, greatly increasing its utility. Expand
The embryonic cell lineage of the nematode Caenorhabditis elegans.
It is concluded that the cell lineage itself, complex as it is, plays an important role in determining cell fate and is demonstrated to demonstrate substantial cell autonomy in at least some sections of embryogenesis. Expand
Genome linking with yeast artificial chromosomes
The technique involves the ligation of large genomic fragments into a vector that provides centromeric, telomeric and selective functions; the constructs are then introduced into Saccharomyces cerevisiae, and replicate in the same manner as the host chromosomes. Expand
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.
These cell lineages range in length from one to eight sequential divisions and lead to significant developmental changes in the neuronal, muscular, hypodermal, and digestive systems and are determined by direct observation of the divisions, migrations, and deaths of individual cells in living nematodes. Expand
Finishing the euchromatic sequence of the human genome
The near-complete sequence reported here should serve as a firm foundation for biomedical research in the decades ahead and greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Expand
Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans.
Twenty-four mutants that alter the normally invariant post-embryonic cell lineages of the nematode Caenorhabditis elegans have been isolated and genetically characterized, suggesting that their phenotypes result from the complete absence of gene activity. Expand
The Sequence of the Human Genome
Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems are indicated. Expand
Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans.
The phenotypes of cell lineage mutants of the nematode Caenorhabditis elegans are described, which define 14 genes, which differ in the breadth and nature of their phenotypic defects. Expand
Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans.
Because it is likely that the authors are approaching saturation of genes affecting primarily the microtubule cells, there appear to be relatively few genes that affect the growth and function of this class of cells and no others. Expand