Sir Charles Sherrington's the integrative action of the nervous system: a centenary appreciation.

  title={Sir Charles Sherrington's the integrative action of the nervous system: a centenary appreciation.},
  author={Robert E Burke},
  journal={Brain : a journal of neurology},
  volume={130 Pt 4},
  • R. Burke
  • Published 21 November 2006
  • Medicine, Psychology
  • Brain : a journal of neurology
In 1906 Sir Charles Sherrington published The Integrative Action of the Nervous System, which was a collection of ten lectures delivered two years before at Yale University in the United States. In this monograph Sherrington summarized two decades of painstaking experimental observations and his incisive interpretation of them. It settled the then-current debate between the "Reticular Theory" versus "Neuron Doctrine" ideas about the fundamental nature of the nervous system in mammals in favor… Expand
Sir Charles Scott Sherrington (1857–1952)
Twentieth century bore witness to remarkable scientists who have advanced our understanding of the brain. Among them, Sir Charles Scott Sherrington’s ideas about the way in which the central nervousExpand
Pioneers in CNS inhibition: 2. Charles Sherrington and John Eccles on inhibition in spinal and supraspinal structures
The contributions of the English neurophysiologist, Charles Scott Sherrington, and his Australian PhD trainee and collaborator, John Carew Eccles, to the concept of central inhibition in the spinal cord and brain are reviewed. Expand
The emergence of the “motoneuron concept”: From the early 19th C to the beginning of the 20th C
This article addresses the emergence of the "motoneuron concept," i.e., the idea that this cell had properties of particular advantage for its control of muscle activation. The motor function of theExpand
The International Brain Commission (1903–1914)
We wish to highlight the political impact of neuroscientific societies as forums of cross-border communication from a historical point of view. We trace the efforts of Constantin von Monakow, aExpand
Harvey Cushing's Wanderjahr (1900-1901).
Harvey Cushing's 14-month Wanderjahr had a profound effect on his subsequent personal career which, in turn, ushered in the modern age of American neurosurgery. From July 1900 to August 1901, heExpand
The Formation and Structure of Synapses
The study of synapses has revealed ultrastructural details of synaptic structure as well as an understanding of how the nervous system assembles synapses during nervous system development. Expand
Innovations, advances, and updates in neurosurgery
Neuroscience plays an important role in the basic study to control the coordination of the human body, thinking, and behavioral patterns that keeps pace with time. It is a complex andExpand
Plants have neither synapses nor a nervous system.
Plants do not have any structures resembling animal synapses, and the phloem is undoubtedly a conduit for the propagation of electrical signaling, but the characteristics of this process are in no way comparable to the events underlying information processing in neuronal networks. Expand
Homeostasis and the concept of 'interstitial fluids hierarchy': Relevance of cerebrospinal fluid sodium concentrations and brain temperature control (Review)
According to this proposal, the brain ISF represents the real internal medium since the maintenance of its dynamic intra-set-range homeostasis is the main factor for a free and independent life of higher vertebrates. Expand
Aspects on the integrative actions of the brain from neural networks to “brain-body medicine”
A holistic approach to the brain-body complex as an indissoluble system has been proposed and the hypothesis has been introduced on the existence of a brain- body integrative structure formed by the area postrema/nucleus tractus solitarius and the “anteroventral third ventricle region/basal hypothalamus with the median eminence” (AV3V-BH). Expand


Charles Scott Sherrington's Integrative Action: a centenary notice
  • C. Breathnach
  • Medicine
  • Journal of the Royal Society of Medicine
  • 2004
Charles Scott Sherrington pointed out that reflexes had to be goaldirected, and that ‘the purpose of a reflex serves as legitimate and urgent an object for natural inquiry as the purpose of colouring of an insect or blossom’. Expand
Sherrington's concept of integrative action
In one of the most sustainedly productive careers in the annals of science, his writings covering a span of sixty-nine years, the English neurophysiologist Sir Charles Scott Sherrington (18591952)Expand
The Discovery of Reflexes
By telling the story of the discovery of reflexes up to 1906, when The Integrative Action of the Nervous System was published, Professor Liddell has skillfully pointed out Sherrington's great contribution. Expand
Sherrington, Physiologist, Philosopher, and Poet.
The fourth of the Sherrington Lectures deals with Sherrington himself. It is a warm but critical appraisal of Sherrington which throws light not only on the subject but on the author. For those whoExpand
Life in Sherrington's laboratory His last decade at Oxford 1925–1935
  • J. Eccles
  • Psychology
  • Trends in Neurosciences
  • 1982
This year masks the fiftieth anniversary of the Nobel Prize tor physiology or medicine awarded to Charles Scott Sherringtou and Edgar Douglas Adrian "for their discoveries regarding the function ofExpand
Some aspects of Sherrington’s contribution to neurophysiology
  • J. Eccles
  • Sociology
  • Notes and Records of the Royal Society of London
  • 1957
Since this year we are celebrating the centenary of Sherrington’s birth, it is fitting that we should try to understand and appreciate the significance of his life. Doubtless we still live too closeExpand
Selected Writings of Sir Charles Sherrington
NEUROLOGISTS will open this volume with the highest expectations and will not be disappointed. It is a testimonial to Sir Charles Sherrington made up of extracts from his writings and edited by aExpand
The Integrative Action of the Nervous System
THE unravelling of the arrangement and complications of the nervous system has always been of great interest not only to physiologists, but also to mankind in general. The specially human attributesExpand
Histology of the Nervous System of Man and Vertebrates
A major neuroanatomic debate during the last quarter of the 19th century centered on the nature of connections between nerve cells, with Camillo Golgi support of a hypothesis that neurons were connected in a continuous reticulum or syncytium. Expand
Reflexes and Motor Integration