Sir Antagonist 1 (San1) is a ubiquitin ligase.

@article{Dasgupta2004SirA1,
  title={Sir Antagonist 1 (San1) is a ubiquitin ligase.},
  author={Arindam Dasgupta and Kerrington L Ramsey and Jeffrey S Smith and David T. Auble},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 26},
  pages={
          26830-8
        }
}
Mutations in Sir Antagonist 1 (SAN1) suppress defects in SIR4 and SPT16 in Saccharomyces cerevisiae. San1 contains a RING domain, suggesting that it functions by targeting mutant sir4 and spt16 proteins for degradation by a ubiquitin-mediated pathway. Consistent with this idea, mutant sir4 and spt16 proteins are unstable in SAN1 cells but are stabilized in san1Delta cells. We demonstrate that San1 possesses ubiquitin-protein isopeptide ligase activity in vitro, and the ubiquitin-protein… CONTINUE READING

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