Sinus tissue pharmacokinetics after oral administration of amoxicillin/clavulanic acid.


OBJECTIVES The in vitro synergy of the amoxicillin/clavulanic acid combination has not always translated in vivo into clinical superiority compared with amoxicillin alone. Specifically, conflicting reports have disputed the superiority of the combination in the treatment of both acute otitis media and acute sinusitis. One possible reason for this may have… (More)


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