Sinus histiocytosis with massive lymphadenopathy.

  title={Sinus histiocytosis with massive lymphadenopathy.},
  author={Stefano Sacchi and Tullio Artusi and Umberto Torelli and Giovanni Emilia},
  journal={Leukemia & lymphoma},
  volume={7 3},
To date, the morphological aspects of sinus histiocytosis with massive lymphadenopathy (SHML) have been fully described. The disease is characterized by an enlargement of lymph nodes in which the sinuses are dilated and infiltrated by histiocytes, often phagocytosing lymphocytes. Even if the prognosis is usually benign and not requiring therapy, several fatal cases have been reported. The etiology is still obscure and the biology is not yet completely clear. Recent immunophenotypical studies… CONTINUE READING