Sinularin induces DNA damage, G2/M phase arrest, and apoptosis in human hepatocellular carcinoma cells

  title={Sinularin induces DNA damage, G2/M phase arrest, and apoptosis in human hepatocellular carcinoma cells},
  author={Ting-Wen Chung and Shih-Chao Lin and Jui Hsin Su and Yu-Kuo Chen and Chi-Chien Lin and Hong-Lin Chan},
  journal={BMC Complementary and Alternative Medicine},
BackgroundSinularin isolated from the cultured soft coral Sinularia flexibilis has been reported to exert potent cytotoxic effects against particular types of cancer. This study was carried out to investigate the cytotoxic effects in sinularin-treated human hepatocellular carcinoma cells, HepG2, and to subsequently explore the underlying molecular mechanisms.MethodsTheMTT (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyl- tetrazolium bromide) method was used to evaluate the cytotoxicity of sinularin… 

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