Sinonasal epithelial cell expression of Toll-like receptor 9 is elevated in cystic fibrosis-associated chronic rhinosinusitis.

@article{Melvin2013SinonasalEC,
  title={Sinonasal epithelial cell expression of Toll-like receptor 9 is elevated in cystic fibrosis-associated chronic rhinosinusitis.},
  author={Thuy-Anh N. Melvin and Andrew P Lane and Mai-Tien Nguyen and Sandra Y. Lin},
  journal={American journal of rhinology & allergy},
  year={2013},
  volume={27 1},
  pages={30-3}
}
BACKGROUND Cystic fibrosis (CF) patients frequently suffer from chronic rhinosinusitis (CRS). The extent to which alterations in sinonasal innate immunity contribute to this disease process is unknown. Activation of sinonasal epithelial cell (SNEC) Toll-like receptors (TLRs), an important component of the innate immune system, may be associated with the hyperinflammatory state observed in sinonasal mucosa of CF patients with CRS. This study compares expression of Toll-like receptor 9 (TLR9), in… CONTINUE READING
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