Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147

@article{Ou2010SinomenineRI,
  title={Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147},
  author={Yangqiong Ou and Weidong Li and Xuejun Li and Zhibin Lin and Min Li},
  journal={Rheumatology International},
  year={2010},
  volume={31},
  pages={1479-1485}
}
CD147 expressed by monocytes, macrophages, and synoviocytes cells can stimulate the production of matrix metalloproteinases (MMPs) associated with the development of rheumatoid arthritis (RA). We investigated the effects of Sinomenine (SIN) on invasion and migration ability and gene expression of CD147, MMP-2, MMP-9 of fibroblast-like synoviocytes cells (FLS) co-cultured with activated human monocytic THP-1 cells (A-THP-1) in vitro. SIN is a pure alkaloid extracted from the Chinese medical… CONTINUE READING

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Preventive effect of co-administration of water containing magnesium ion on indomethacin induced lesions of gastric mucosa in adjuvant-induced arthritis rat

  • N Noriaki, F Takashi, I Yoshimasa, U Shigeyuki, H Kazuyuki
  • 2009
1 Excerpt

Inhibitory effect of Uncaria sinensis on human aortic smooth muscle cell migration is based on matrix metalloproteinase-9 inhibitory

  • H Tae, KW Kim, SJ Suh, CG Kwak, JK Kima, CH Kimb
  • Environ Toxicol Phar
  • 2007
1 Excerpt

Effect of sinomenine on gene expression of the IL-1bactivated human synovial sarcoma

  • XJ Li, YK Patrick, WY Ha, YL Daisy, MY Mandy, PX Wang
  • Life Sci
  • 2006
1 Excerpt