Sinomenine promotes differentiation but impedes maturation and co-stimulatory molecule expression of human monocyte-derived dendritic cells.

@article{Chen2007SinomeninePD,
  title={Sinomenine promotes differentiation but impedes maturation and co-stimulatory molecule expression of human monocyte-derived dendritic cells.},
  author={Yongwen Chen and Chengying Yang and Naishi Jin and Zhunyi Xie and Lie Fei and Zhengcai Jia and Yu-zhang Wu},
  journal={International immunopharmacology},
  year={2007},
  volume={7 8},
  pages={1102-10}
}
Dendritic cells (DC) excel at presenting antigen to T cells and thus make a key contribution to the induction of primary and secondary immune responses. Sinomenine has been used for centuries in the treatment of patients with autoimmune diseases as it possesses immunosuppressive and anti-inflammatory activities. However, the effect of sinomenine on the differentiation, maturation, and functionality of DC derived from monocytes has not been studied. We show here that DC differentiation is… CONTINUE READING

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