Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression.

@article{Takeshita2004SinoatrialND,
  title={Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression.},
  author={Kyosuke Takeshita and Toshihiko Fujimori and Yoko Kurotaki and Haruo Honjo and Hiroshi Tsujikawa and Kenji Yasui and Jong-Kook Lee and Kaichiro Kamiya and Kiyoyuki Kitaichi and Koji Yamamoto and Masafumi Ito and Takahisa Kondo and Shigeo Iino and Yasuya Inden and Makoto Hirai and Toyoaki Murohara and Itsuo Kodama and Yo-ichi Nabeshima},
  journal={Circulation},
  year={2004},
  volume={109 14},
  pages={
          1776-82
        }
}
BACKGROUND Homozygous mutant mice with a defect of klotho gene expression (kl/kl) show multiple age-related disorders and premature death from unknown causes. METHODS AND RESULTS The kl/kl mice subjected to 20-hour restraint stress showed a high rate (20/30) of sudden death, which was associated with sinoatrial node dysfunction (conduction block or arrest). Heart rate and plasma norepinephrine of kl/kl mice, unlike those of wild-type (WT) mice, failed to increase during the stress. Intrinsic… CONTINUE READING

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