Singlet oxygen induces collagenase expression in human skin fibroblasts.

  title={Singlet oxygen induces collagenase expression in human skin fibroblasts.},
  author={Karin Scharffetter-Kochanek and Meinhard Wlaschek and Karlis Briviba and Helmut Sies},
  journal={FEBS letters},
  volume={331 3},
Singlet oxygen generated in a dark reaction by thermodissociation of an endoperoxide (NDPO2) elicits an increase in mRNA of interstitial collagenase (MMP-1) in cultured human fibroblasts. The effect is enhanced in deuterium oxide-based medium and is abolished in the presence of non-toxic doses of sodium azide. In contrast, the mRNA level of the tissue inhibitor of metalloproteinases (TIMP-1) remains unaltered under these experimental conditions. These observations support the suggestion that an… CONTINUE READING

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