Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation

  title={Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation},
  author={Christopher P. Stanley and G. Maghzal and A. Ayer and Jihan Talib and Andrew M. Giltrap and S. Shengule and Kathryn Wolhuter and Yutang Wang and Preet C Chadha and C. Suarna and Oleksandra Prysyazhna and Jenna Scotcher and L. Dunn and F. Prado and N. Nguyen and Jephthah O. Odiba and J. Baell and Johannes-Peter Stasch and Y. Yamamoto and P. Mascio and P. Eaton and R. J. Payne and R. Stocker},
  • Christopher P. Stanley, G. Maghzal, +20 authors R. Stocker
  • Published 2019
  • Chemistry, Medicine
  • Nature
  • Singlet molecular oxygen (1O2) has well-established roles in photosynthetic plants, bacteria and fungi1–3, but not in mammals. Chemically generated 1O2 oxidizes the amino acid tryptophan to precursors of a key metabolite called N-formylkynurenine4, whereas enzymatic oxidation of tryptophan to N-formylkynurenine is catalysed by a family of dioxygenases, including indoleamine 2,3-dioxygenase 15. Under inflammatory conditions, this haem-containing enzyme is expressed in arterial endothelial cells… CONTINUE READING
    27 Citations
    Generation of Singlet Molecular Oxygen by Lipid Hydroperoxides and Nitronium Ion†
    Biochemical basis and metabolic interplay of redox regulation
    • 35
    l-Tryptophan–Induced Vasodilation Is Enhanced in Preeclampsia
    • 2
    Novel vasodilatory factor identified
    • PDF


    Human Indoleamine 2,3-Dioxygenase Is a Catalyst of Physiological Heme Peroxidase Reactions
    • 36
    • PDF
    Post-translational Regulation of Human Indoleamine 2,3-Dioxygenase Activity by Nitric Oxide*
    • 77
    • PDF
    Kynurenine is an endothelium-derived relaxing factor produced during inflammation
    • 299
    • PDF
    Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice.
    • 682
    • PDF
    Indoleamine 2,3-dioxygenase. Kinetic studies on the binding of superoxide anion and molecular oxygen to enzyme.
    • 53
    Cysteine Redox Sensor in PKGIa Enables Oxidant-Induced Activation
    • 393
    Studies on indoleamine 2,3-dioxygenase. I. Superoxide anion as substrate.
    • 133
    Singlet oxygen production by biological systems.
    • J. Kanofsky
    • Chemistry, Medicine
    • Chemico-biological interactions
    • 1989
    • 215
    Enzyme Reactivation by Hydrogen Peroxide in Heme-based Tryptophan Dioxygenase*
    • 33
    • PDF