Single-stranded DNA binding activity of C1-tetrahydrofolate synthase enzymes.

  title={Single-stranded DNA binding activity of C1-tetrahydrofolate synthase enzymes.},
  author={Wayne P Wahls and Jae Mahn Song and Gerald R Smith},
  journal={The Journal of biological chemistry},
  volume={268 32},
In eukaryotes C1-5,6,7,8-tetrahydrofolate (THF) synthase is a trifunctional enzyme that catalyzes the interconversion of reduced forms of folate to supply activated one-carbon units required for a variety of metabolic pathways. The enzymatic activities include 10-formyl-THF synthetase (EC, 5,10-methenyl-THF cyclohydrolase (EC, and 5,10-methylene-THF dehydrogenase (EC In bacteria separate, monofunctional or bifunctional polypeptides catalyze the same reactions. We… CONTINUE READING


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