Single-step assays to analyze CYP2D6 gene polymorphisms in Asians: allele frequencies and a novel *14B allele in mainland Chinese.

@article{Ji2002SinglestepAT,
  title={Single-step assays to analyze CYP2D6 gene polymorphisms in Asians: allele frequencies and a novel *14B allele in mainland Chinese.},
  author={Ling Fen Ji and Shixiu Pan and Jacqueline Marti-Jaun and Edgar Haenseler and Katharina Rentsch and Martin Hersberger},
  journal={Clinical chemistry},
  year={2002},
  volume={48 7},
  pages={983-8}
}
BACKGROUND Cytochrome P450-dependent monooxygenase 2D6 (CYP2D6) activity can be estimated by investigating the metabolism of model drugs or by genotyping the most common CYP2D6 alleles. For Caucasians, the CYP2D6 allele frequencies are well investigated, and single-step assays are available for genotyping, whereas allele analysis in mainland Chinese is limited. METHODS Two tetra-primer assays and one allele-specific amplification assay were developed to easily genotype the CYP2D6 alleles *8… CONTINUE READING

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