Single sperm typing demonstrates that reduced recombination is associated with the production of aneuploid 24,XY human sperm.

@article{Shi2001SingleST,
  title={Single sperm typing demonstrates that reduced recombination is associated with the production of aneuploid 24,XY human sperm.},
  author={Qinghua Shi and Elizabeth Spriggs and Leigh L. Field and Evelyn Ko and Leona Barclay and R. H. Martin},
  journal={American journal of medical genetics},
  year={2001},
  volume={99 1},
  pages={34-8}
}
To account for the increased proportion of paternal nondisjunction in 47,XXY males as compared to other trisomies, it has been suggested that the XY bivalent, with its reduced region of homology, is particularly susceptible to nondisjunction. Molecular studies of liveborn Klinefelter syndrome (47,XXY) individuals have reported an association between the absence of recombination in the pseudoautosomal region and nondisjunction of the XY bivalent. In this study we examined single sperm from a… CONTINUE READING