Single sevoflurane exposure decreases neuronal nitric oxide synthase levels in the hippocampus of developing rats.


BACKGROUND The use of general anaesthetics in young children and infants has raised concerns regarding the adverse effects of these drugs on brain development. Sevoflurane might have harmful effects on the developing brain; however, these effects have not been well investigated. METHODS Postnatal day 7 (P7) Sprague-Dawley rats were continuously exposed to… (More)
DOI: 10.1093/bja/aes121