Single-round infectious particles enhance immunogenicity of a DNA vaccine against West Nile virus

@article{Chang2008SingleroundIP,
  title={Single-round infectious particles enhance immunogenicity of a DNA vaccine against West Nile virus},
  author={David C. Chang and Wen Jun Liu and Itaru Anraku and D. Christopher Clark and Christopher Charles Pollitt and Andreas Suhrbier and Roy Hall and Alexander A Khromykh},
  journal={Nature Biotechnology},
  year={2008},
  volume={26},
  pages={571-577}
}
DNA vaccines encoding replication-defective viruses are safer than inactivated or live attenuated viruses but may fail to stimulate an immune response sufficient for effective vaccination. We augment the protective capacity of a capsid-deleted flavivirus DNA vaccine by co-expressing the capsid protein from a separate promoter. In transfected cells, the capsid-deleted RNA transcript is replicated and translated to produce secreted virus-like particles lacking the nucleocapsid. This RNA is also… CONTINUE READING

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a commentary

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